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KMID : 0604520110370040327
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Journal of the Society of Cosmetic Scientists of Korea
2011 Volume.37 No. 4 p.327 ~ p.335
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The Effects of Polydatin Isolated from Polygonum cuspidatum on Melanogenesis and Wrinkle Formation
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Jin Mu-Hyun
Jeong Eui-Taek
Kim Mi-Sun
Song Hye-Jin
Kwak Taek-Jong
Park Sun-Gyoo
Lee Sang-Min
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Abstract
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5,4'-dihydroxystilbene-3-O-β-D-glucopyranoside (Polydatin) is one of the stilbenes found in Polygonum cuspidatum (P. cuspidatum), however, the effects of polydatin on skin biology remain to be elucidated. In this study, we obtained polydatin from P. cuspidatum and investigated the effects of polydatin in skin-derived melanocytes and fibroblasts. In melanocytes, polydatin inhibited not only the tyrosinase activity and melanin production but the expression of melanogenic factors, tyrosinase and microphthalmia-associated transcription factor (MITF). In addition, the level of type I procollagen in fibroblasts was analyzed, and polydatin significantly induced the production of type I procollagen in a dose-dependent manner. Finally we conformed that topical treatment of polydatin improved wrinkle and induced whitening of human skin in vivo. These data provide evidence that polydatin can be a potent candidate for the improvement of both skin wrinkle and whitening from the point of industry view.
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KEYWORD
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Polygonum cuspidatum, 5, 4'-dihydroxystilbene-3-O-D-glucopyranoside, melanogenesis, MITF, collagen synthesis
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